Physical healing and time perception

linear regression
hierarchical model
If the body affects the mind and the mind affects the body, it should by possible to influence the body by influencing the mind. This study manipulated perception of time to see if perceived, not actual, time would influence the rate at which wounds heal. Reinterpret a psychological experiment using linear and mixed models.
Author

Alex Reinhart

Published

November 9, 2025

Data files
Data year

2023

Motivation

Recent psychological research has examined the idea of mind-body unity: that physical ailments can cause mental stress, but also that psychological influences can cause physical ailments. For instance, chronic stress might contribute to high blood pressure or chronic pain, and depression might contribute to other physical ailments. But the depth of this connection is not well-understood, so psychologists have designed various studies to explore it. This study looked at the mental perception of time: rather than manipulating mood and seeing how that affects health, the study manipulates how much time participants feel has passed, to see if that affects the rate at which the body heals.

The study was based on cupping, which involves placing a suction cup on the skin and applying light suction. This increases blood flow to the area, which certain alternative medicine practitioners believe can help with various medical conditions, and typically also causes a red mark on the skin. The rate at which these marks disappeared was the measure of healing.

Thirty-three subjects were recruited to the study. Each participant came to the lab three times on different days. During each lab session, they were cupped in a particular location: Session 1 cupped their upper forearm, session 2 cupped the middle of their forearm, and session 3 cupped their lower forearm. Each session was also assigned to one of three conditions, with every participant receiving every condition in a random order:

  1. Slow Time (14 min)
  2. Normal Time (28 min)
  3. Fast Time (56 min)

The condition is based on the manipulation of time used in the experiment. While waiting for the cupping mark to disappear, the participants played Tetris, and at regular intervals they were presented a short survey asking how much the mark had healed. These surveys were ostensibly every 2, 4, or 8 minutes in the slow, normal, and fast conditions, but actually were always every 4 minutes. As their phones and watches were confiscated at the start of the session, the participants could only use the clock on the lab computer screen, which was faked to match the time manipulation. Thus they were manipulated into thinking time was passing faster or slower than it really was. Participants in the slow time condition thought only 14 minutes had passed, when in fact 28 minutes actually had, and so on.

At the beginning and end of the experiment, the experimenters took photos of the participant’s arm. These photos were used to rate how much the cupping mark healed during the 28-minute window. Ratings were provided by workers on Amazon Mechanical Turk who were provided the photos and asked to rate healing on a 0 to 10 scale. Multiple workers were used to rate every photo, in the hopes that this would give better estimates than using a single rater.

According to the experimenters, “significantly more healing was observed in the Normal Time condition compared to the Slow Time condition, in the Fast Time condition compared to the Normal Time condition, and in the Fast Time condition compared to the Slow Time condition”

However, Gelman and Brown (2024) argue that instead this study is “fatally flawed in the sense of not providing evidence to support [its] strong claims.” They argue that the hierarchical (mixed-effects) model used to analyze the data was inappropriate, and that with these errors corrected, “the data do not provide strong evidence of the claimed effect”. We can reanalyze the data to explore their objections.

Data

Each observation is one rating by one Mechanical Turk worker, rating the healing for one participant in one session.

Data preview

healing-time.csv

Variable descriptions

Variable Description
Subject Subject ID number
ResponseId Unique ID for each Mechanical Turk rater
Condition Experimental condition: the perceived time in this trial, either 14, 28, or 56 minutes
Session Session number
Healing Amount of healing, based on average of Mechanical Turk workers (0 = not at all healed, 5 = somewhat healed, 10 = completely healed)
Session_Mood Participant’s mood score during the session; scale used not specified
Age Participant age (years)
Gender Gender of the participant
Race Race of the participant
PSS_sum Stress score from the Perceived Stress Scale
Mindfulness Mindfulness estimate from the Langer Mindfulness Scale
Extraversion Extraversion, one of the Big 5 personality traits; scale used not specified
Agreeableness Agreeableness, one of the Big 5 personality traits; scale used not specified
Conscientiousness Conscientiousness, one of the Big 5 personality traits; scale used not specified
Neuroticism Neuroticism, one of the Big 5 personality traits; scale used not specified
Openness Openness, one of the Big 5 personality traits; scale used not specified
Dscale Depression score from the Hospital Anxiety and Depression Scale (0-21, 0 = no depression, 21 = depression)
Ascale Anxiety score from the Hospital Anxiety and Depression Scale (0-21, 0 = no anxiety, 21 = most anxiety)

Questions

  1. Tabulate the participants and sessions. Did every participant attend every session? How many raters rated each participant? Is there any missingness that could be concerning?
  2. The experiment was intended to randomize the order each participant received each condition, so that any time-ordering affects (such as healing improving in later sessions due to some kind of practice or learning effect) would not bias the results. Tabulate the session orderings to see whether they are indeed balanced.
  3. Perform an exploratory data analysis of average healing rating by condition. What evidence do you see of a difference in healing?
  4. Perform an exploratory data analysis comparing the raters. Is there evidence that some of the raters give systematically higher or lower ratings?
  5. Consider using a mixed effects model to estimate the condition effect. What are the sources of variation? What random effects should be included? For fixed effects, start with the simplest possible model, and don’t yet consider the various demographic and psychological variables.
  6. Fit the model you proposed and evaluate the results.
  7. Read the “Reanalysis and Reassessment” by Gelman and Brown (2024) and compare their simple model to yours. What decisions did they make differently? Particularly contrast your choice of random effects, and comment on which choices seem most appropriate.

References

Aungle, P., Langer, E. (2023). Physical healing as a function of perceived time. Scientific Reports 13, 22432. https://doi.org/10.1038/s41598-023-50009-3

See also: Gelman A, Brown NJL (2024). How Statistical Challenges and Misreadings of the Literature Combine to Produce Unreplicable Science: An Example From Psychology. Advances in Methods and Practices in Psychological Science 7(4). https://doi.org/10.1177/25152459241276398